State Council of China introduced the revised Regulation on Safety Control of Dangerous Chemicals in 2-Mar-2011, which would formally enter into force in 1-Dec-20111, and under this newly reformed chemical regulation, which function as the umbrella law, different Ministries and Administration will be involved into implementation and various administrative provisions promulgated accordingly as well, and then the resulting regulatory challenges to chemical industry were concerned and highlighted recently. Within this article, the primary regulatory obligations and related challenges were reviewed.