The Japanese “Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc.” is better known as the “Chemical Substance Control Law” (CSCL). Since its enactment in 1973, it has imposed strict pre-market evaluation of chemical substances to prevent environmental pollution and control chemical risks to human health, plants and animals. It has been amended 3 times in 1986, 2003 and 2009. Full implementation of amended CSCL started from April 1, 2011.