China’s new chemical substance notification system (China NCSN, a.k.a China REACH), has some of the most stringent chemical regulatory requirements in the globe especially in its requirements of eco-toxicity test data. Both Chinese domestic testing institutes and overseas testing institutes can produce data for China NCSN with some qualification conditions. However, some of the eco-toxicity tests are mandatorily required to be conducted on Chinese test organisms in accredited MEP-approved Chinese laboratories (so far 13 in total).